| Title | [Clinical observation of heparin-induced thrombocytopenia.] | | Author(s) | Tian HY, Meng Y, Zhang JB, Ma Q, Cheng GS, Fan FL, Wang J, Wan HM | | Institution | Department of Cardiology and Peripheral Angiopathy, First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, 710061, China. Email: tianhhyy@mail.xjtu.edu.cn. | | Source | Zhonghua Yi Xue Za Zhi 2009 May 26; 89(20):1405-7. | | Abstract | OBJECTIVE: To explore the treatment of heparin-induced thrombocytopenia (HIT) in venous thromboembolism.
METHODS: A total of 202 patients with venous thromboembolism without anticoagulation contraindications were enrolled. All of them were treated with low molecular weight heparin (LMWH) and/or unfractionated heparin (UFH). The peripheral blood cells were examined regularly.
RESULTS: HIT occurred in 6 patients. And argatroban was used to treat HIT. The overall incidence rate of HIT in this study was 2.97%. The time of occurrence of HIT was about Days 3 - 9 after using heparin. The platelet recovered to the basic level at Days 3 - 7 after withdrawing heparin and initiating argatroban.
CONCLUSION: The count of platelet should be measured in the patients receiving regular LMWH and/or UFH therapy. And the above regimen should be discontinued timely when the platelet count declined progressively by over 50%. Argatroban was effective. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19671335 |
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